Fluidized Bed Granulation for Pharmaceutical Applications

Fluid Bed Process

Fluid Bed Processing Animation Courtesy of Techceuticals.

Fluid bed granulation has been a part of solid-dose pharmaceutical manufacturing for decades. The equipment mixes and granulates materials with almost no moving parts. Inside the fluid bed, particles are “fluidized” using a stream of air and a granulating solution mist is added. The liquid binder causes the particles to aggregate and form granules. The equipment can be complex to use, but the process is very controllable when used correctly.

Basic cycles of a fluid bed process include pre-mix, spray, dry, and cooling. The key element of the process is the random distribution of powder with the solution spray which can be a top spray, bottom spray or tangential spray depending upon how the bowls and expansion chambers are configured.

Fluid Bed Granules Processing Coating Wurster

Granules in a fluid bed processed with bottom spray and a wurster column. Photo courtesy of O’Hara Technologies.

The main components of a fluid bed processor (or fluid bed dryer) include the air treatment system, or air handling system; the inlet duct; product bowl; expansion chamber; filter bag; bag house, and turbine.

Top manufacturers of fluid bed equipment for pharmaceutical applications include:

Federal Equipment Company’s “Fluid Bed Dryer / Processor” category includes equipment from these well-known manufacturers of batch and continuous fluid bed dryers. The category also includes parts, bowls, wurster inserts, and many other accessories for pharmaceutical, dietary supplement and food ingredients; and many more applications.

Visit fedequip.com to view our entire inventory of equipment for granulation and solid-dose manufacturing.